Lenstra Lab

Netherlands Cancer Institute

Publications


Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription.
Lenstra TL, Coulon A, Chow CC, Larson DR.
Mol Cell. 2015 Nov 19;60(4):597-610. doi: 10.1016/j.molcel.2015.09.028. Epub 2015 Nov 5.

Transcription Dynamics in Living Cells.
Lenstra TL, Rodriguez J, Chen H, Larson DR.
Annu Rev Biophys. 2016 Jul 5;45:25-47. doi: 10.1146/annurev-biophys-062215-010838. Epub 2016 Apr 27.

Single-Molecule mRNA Detection in Live Yeast.
Lenstra TL, Larson DR.
Curr Protoc Mol Biol. 2016;113:14.24.1-14.24.15. Epub 2016 Jan 4.

A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions.
Sameith K, Amini S, Groot Koerkamp MJ, van Leenen D, Brok M, Brabers N, Lijnzaad P, van Hooff SR, Benschop JJ, Lenstra TL, Apweiler E, van Wageningen S, Snel B, Holstege FC, Kemmeren P.
BMC Biol. 2015 Dec 23;13:112. doi: 10.1186/s12915-015-0222-5.

Cell cycle population effects in perturbation studies.
O'Duibhir E, Lijnzaad P, Benschop JJ, Lenstra TL, van Leenen D, Groot Koerkamp MJ, Margaritis T, Brok MO, Kemmeren P, Holstege FC.
Mol Syst Biol. 2014 Jun 21;10:732. doi: 10.15252/msb.20145172.

Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.
Kemmeren P*, Sameith K*, van de Pasch LA*, Benschop JJ*, Lenstra TL*, Margaritis T*, O'Duibhir E, Apweiler E, van Wageningen S, Ko CW, van Heesch S, Kashani MM, Ampatziadis-Michailidis G, Brok MO, Brabers NA, Miles AJ, Bouwmeester D, van Hooff SR, van Bakel H, Sluiters E, Bakker LV, Snel B, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Holstege FC.
Cell. 2014 Apr 24;157(3):740-52. doi: 10.1016/j.cell.2014.02.054.
*These authors contributed equally

The role of Ctk1 kinase in termination of small non-coding RNAs.
Lenstra TL*, Tudek A*, Clauder S, Xu Z, Pachis ST, van Leenen D, Kemmeren P, Steinmetz LM, Libri D, Holstege FC.
PLoS One. 2013 Dec 4;8(12):e80495. doi: 10.1371/journal.pone.0080495. eCollection 2013.
*These authors contributed equally

Kinetochore function and chromosome segregation rely on critical residues in histones H3 and H4 in budding yeast.
Ng TM, Lenstra TL, Duggan N, Jiang S, Ceto S, Holstege FC, Dai J, Boeke JD, Biggins S.
Genetics. 2013 Nov;195(3):795-807. doi: 10.1534/genetics.113.152082. Epub 2013 Sep 13.

Systematic triple-mutant analysis uncovers functional connectivity between pathways involved in chromosome regulation.
Haber JE, Braberg H, Wu Q, Alexander R, Haase J, Ryan C, Lipkin-Moore Z, Franks-Skiba KE, Johnson T, Shales M, Lenstra TL, Holstege FC, Johnson JR, Bloom K, Krogan NJ.
Cell Rep. 2013 Jun 27;3(6):2168-78. doi: 10.1016/j.celrep.2013.05.007. Epub 2013 Jun 6.

A novel role for Sem1 and TREX-2 in transcription involves their impact on recruitment and H2B deubiquitylation activity of SAGA.
García-Oliver E, Pascual-García P, García-Molinero V, Lenstra TL, Holstege FC, Rodríguez-Navarro S.
Nucleic Acids Res. 2013 Jun;41(11):5655-68. doi: 10.1093/nar/gkt272. Epub 2013 Apr 17.

Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis.
Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP.
Sci Signal. 2013 Mar 26;6(268):ra21. doi: 10.1126/scisignal.2003848.

The discrepancy between chromatin factor location and effect.
Lenstra TL, Holstege FC.
Nucleus. 2012 May-Jun;3(3):213-9. doi: 10.4161/nucl.19513. Epub 2012 May 1.

A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.
Verzijlbergen KF, van Welsem T, Sie D, Lenstra TL, Turner DJ, Holstege FC, Kerkhoven RM, van Leeuwen F.
PLoS Genet. 2011 Oct;7(10):e1002284. doi: 10.1371/journal.pgen.1002284. Epub 2011 Oct 6.

The specificity and topology of chromatin interaction pathways in yeast.
Lenstra TL, Benschop JJ, Kim T, Schulze JM, Brabers NA, Margaritis T, van de Pasch LA, van Heesch SA, Brok MO, Groot Koerkamp MJ, Ko CW, van Leenen D, Sameith K, van Hooff SR, Lijnzaad P, Kemmeren P, Hentrich T, Kobor MS, Buratowski S, Holstege FC.
Mol Cell. 2011 May 20;42(4):536-49. doi: 10.1016/j.molcel.2011.03.026.

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.
Daugeron MC*, Lenstra TL*, Frizzarin M, El Yacoubi B, Liu X, Baudin-Baillieu A, Lijnzaad P, Decourty L, Saveanu C, Jacquier A, Holstege FC, de Crécy-Lagard V, van Tilbeurgh H, Libri D.
Nucleic Acids Res. 2011 Aug;39(14):6148-60. doi: 10.1093/nar/gkr178. Epub 2011 Apr 1.
*These authors contributed equally

Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.
Stulemeijer IJ, Pike BL, Faber AW, Verzijlbergen KF, van Welsem T, Frederiks F, Lenstra TL, Holstege FC, Gasser SM, van Leeuwen F.
Epigenetics Chromatin. 2011 Feb 3;4(1):2. doi: 10.1186/1756-8935-4-2.

Functional overlap and regulatory links shape genetic interactions between signaling pathways.
van Wageningen S, Kemmeren P, Lijnzaad P, Margaritis T, Benschop JJ, de Castro IJ, van Leenen D, Groot Koerkamp MJ, Ko CW, Miles AJ, Brabers N, Brok MO, Lenstra TL, Fiedler D, Fokkens L, Aldecoa R, Apweiler E, Taliadouros V, Sameith K, van de Pasch LA, van Hooff SR, Bakker LV, Krogan NJ, Snel B, Holstege FC.
Cell. 2010 Dec 10;143(6):991-1004. doi: 10.1016/j.cell.2010.11.021.