Lenstra Lab

Netherlands Cancer Institute, Oncode Institute

Current lab members

Tineke Lenstra

Principle Investigator
+31 (0)20 512 7889
 [email protected]
View Tineke Lenstra's LinkedIn profile LinkedIn profile
  ResearchGate profile


About Tineke

Tineke Lenstra received her Bachelor's' and Master's' degree in biomedical sciences from Utrecht University (cum laude). In 2008, she joined the laboratory of Frank Holstege at University Medical Centre Utrecht, where she used genome-wide expression analysis to study transcription regulatory complexes. She was awarded a cum laude PhD in 2012. As a postdoc in laboratory of Dan Larson at the National Cancer Institute in Bethesda, USA, she used cutting-edge single-molecule techniques to study transcription dynamics in single cells. In 2016, she established an independent group at the Netherlands Cancer Institute (NKI) in Amsterdam, and in 2019, she joined Oncode Institute. Her lab focuses on the regulatory mechanisms of stochastic transcription in eukaryotic cells.

For her work, Tineke has received a number of awards, including the NVBMB prize, the Fellows Award for Research Excellence, the NCI Director's Innovation Award and the “Cancer Genomics and Developmental Biology” PhD Student Award. Her research was supported by the ERC starting grant, CancerGenomics.nl, EMBO long-term fellowships, KWF fellowship for basic research, the NWO Toptalent Program and Huygens Scholarship Talent Program.

Ineke Brouwer

Postdoc
[email protected]


About Ineke

In 2011, I graduated as a MSc in Physics from the Vrije Universiteit in Amsterdam. Subsequently, I did a PhD in single-molecule biophysics at the Vrije Universiteit in Amsterdam which I completed in 2016. During my PhD I used a combination of optical trapping and fluorescence microscopy to study different biological processes. I joined Tineke Lenstra's group in 2017 studying transcription regulation in live cells.

Wim de Jonge

Postdoc
[email protected]


About Wim

After obtaining a master’s degree in molecular and cellular life sciences from the Utrecht University, I continued in Utrecht to do a PhD in the lab of Frank Holstege.During my PhD I used genome-wide techniques to study transcription regulation dynamics. In Tineke Lenstra’s lab I use microscopy-based techniques to study dynamics of transcription regulation in single cells at single molecule resolution.

Wim Pomp

Technical specialist
[email protected]


About Wim

For a physicist as myself, biology provides a huge pool of interesting challenges which enhance our understanding of life, and generate exciting new physics. As such, I completed my PhD in Leiden in Thomas Schmidt's group by looking at the interaction between shape and biological function. After that I briefly worked on the retromer system, which recycles certain proteins. In Tineke Lenstra's group I will be employing a novel system which will give us insight in RNA transcription.

Heta Patel

PhD student
[email protected]


About Heta

I received my bachelor's degrees in 2015 from the University of California, Santa Cruz in pure math and biochemistry and molecular biology. For the next two years, I did various internships at the National Institutes of Health, where I met my current supervisor, Tineke Lenstra. I joined her group in 2017 as a PhD student to study the effects of DNA topological constraints on transcriptional bursting.

Gert-Jan Kuijntjes

PhD student
[email protected]


About Gert-Jan

I studied Cell Biology at Utrecht University and obtained my master's degree in 2018. After graduating, I joined the groups of Tineke Lenstra (NKI) and John van Noort (Leiden University) as a PhD student. In this shared project I will study the link between the transcription of genes and their DNA structure at single cell level.

Marit de Kort

PhD student
[email protected]


About Marit

I obtained my Msc in biomedical sciences at Utrecht University in 2019. My internships were performed at the labs of prof. Holstege at the Princess Maxima Center in Utrecht and of prof. Hochedlinger at the Massachusetts General Hospital in Boston. In 2020, I started my PhD in the lab of Tineke Lenstra, where I will study transcription dynamics in mammalian cells, using microscopy.

Jos Meeussen

PhD student
[email protected]


About Jos

In 2017, I started a MSc in Molecular Life Sciences at Wageningen University & Research. During this study, I have developed a specific interest for the dynamics and biochemical mechanisms of protein-DNA interactions, as well as the single-molecule imaging techniques used to study these. This fascination has led me to the group of Tineke Lenstra for my PhD, where I will use these imaging techniques to study transcription factor clustering in budding yeast.

Aleksandra Balwierz

Technician
[email protected]


About Alexandra

I graduated from Jagiellonian University in Krakow, Poland with a master's degree in Medical Biotechnology. After gaining research experience in structural biology and epigenetic laboratories, I joined the graduate school at German Cancer Research Center in Heidelberg, where I studied the role of miRNAs in cancer cell signaling. In 2016 I joined Tineke Lenstra's group as a technician where I will participate in the study of transcription dynamics in eukaryotes using cutting-edge single-molecule microscopy techniques.

Linda Joosen

Technician
[email protected]


About Linda

I graduated in 2008 with a Bachelors degree in Molecular Research. During my internship in Clinical Genetics, and later on work as a research technician and trainer in Cell Biology, I obtained a fascination for microscopy technologies and the capabilities with it in scientific field. In 2019, I joined the group of Tineke Lenstra as a technician to study transcription regulation in living cells with the use of advanced single-molecule techniques.

Stefano Coppola

Postdoc
[email protected]


About Stefano

Tba

Alumni

Biljana Atanasovska