Tineke Lenstra received her Bachelor's' and Master's' degree in biomedical sciences from Utrecht University (cum laude). In 2008, she joined the laboratory of Frank Holstege at University Medical Centre Utrecht, where she used genome-wide expression analysis to study transcription regulatory complexes. She was awarded a cum laude PhD in 2012. As a postdoc in laboratory of Dan Larson at the National Cancer Institute in Bethesda, USA, she used cutting-edge single-molecule techniques to study transcription dynamics in single cells. In 2016, she established an independent group at the Netherlands Cancer Institute (NKI) in Amsterdam, where her lab focuses on the regulatory mechanisms of stochastic transcription in eukaryotic cells.
For her work, Tineke has received a number of awards, including the “Cancer Genomics and Developmental Biology” PhD Student Award, the Fellows Award for Research Excellence and the NCI Director's Innovation Award. Her research was supported by the Huygens Scholarship Talent Program, the NWO Toptalent Program, EMBO long-term fellowships and KWF fellowship for basic research.
In 2011, I graduated as a MSc in Physics from the Vrije Universiteit in Amsterdam. Subsequently, I did a PhD in single-molecule biophysics at the Vrije Universiteit in Amsterdam which I completed in 2016. During my PhD I used a combination of optical trapping and fluorescence microscopy to study different biological processes. I joined Tineke Lenstra's group in 2017 studying transcription regulation in live cells.
Trained as a biologist, I received my bachelor degree from the University Ss. Cyril and Methodius, Faculty of Natural Sciences and Mathematics in Skopje, Macedonia. In 2013, I graduated as a MSc in Health Sciences (Genetic Epidemiology) from the Erasmus Medical Center in Rotterdam. The same year I started my PhD training at the University Medical Center Groningen. My PhD research was focused on detecting and characterizing the role of long non-coding RNAs in liver diseases using transcriptomics, genomics and experimental approaches. In 2018, I joined the group of Tineke Lenstra to study the dynamics and mechanisms of eukaryotic transcription.
For a physicist as myself, biology provides a huge pool of interesting challenges which enhance our understanding of life, and generate exciting new physics. As such, I completed my PhD in Leiden in Thomas Schmidt's group by looking at the interaction between shape and biological function. After that I briefly worked on the retromer system, which recycles certain proteins. In Tineke Lenstra's group I will be employing a novel system which will give us insight in RNA transcription.
I received my bachelor's degrees in 2015 from the University of California, Santa Cruz in pure math and biochemistry and molecular biology. For the next two years, I did various internships at the National Institutes of Health, where I met my current supervisor, Tineke Lenstra. I joined her group in 2017 as a PhD student to study the effects of DNA topological constraints on transcriptional bursting.
I studied Cell Biology at Utrecht University and obtained my master's degree in 2018. After graduating, I joined the groups of Tineke Lenstra (NKI) and John van Noort (Leiden University) as a PhD student. In this shared project I will study the link between the transcription of genes and their DNA structure at single cell level.
I graduated from Jagiellonian University in Krakow, Poland with a master's degree in Medical Biotechnology. After gaining research experience in structural biology and epigenetic laboratories, I joined the graduate school at German Cancer Research Center in Heidelberg, where I studied the role of miRNAs in cancer cell signaling. In 2016 I joined Tineke Lenstra's group as a technician where I will participate in the study of transcription dynamics in eukaryotes using cutting-edge single-molecule microscopy techniques.
In 2017, I started a MSc in Molecular Life Sciences at Wageningen University & Research. During this study, I have developed a specific interest for the dynamics and biochemical mechanisms of protein-DNA interactions, as well as the single-molecule imaging techniques used to study these. This fascination has led me to the group of Tineke Lenstra for my internship, where I will use these imaging techniques to study transcription factor clustering in budding yeast.